Block completion of lectures and exercises; Seminar work (experimental design protocol); Exam

Training in animal welfare, ethics and law within EU, good practice in animal experimentation design

Ethics, bio-ethics, UE legislation in the animal protection in research, animal models, model selection, clinical experiments, animal welfare

Lectures:

Lecture: 1. From Aristotle to today – the history of animal experimentation.

Lecture: 2. Animal models and their use in biomedical research. Animal ethics and welfare. Alternatives to animal experimentation.

Lecture: 3. International practice and legislation.

Lecture: 4. Present role of laboratory animals.

Lecture: 5. Applying the 3Rs in project design.

Lecture: 6. Human endpoints and clinical experiments in animals. Study design, statistics for data evaluation. Case studies and class discussions to provide materials and ideas for school presentations.

Practicals:

Environmental requirements for individual species.

Behavioural ecology in animal welfare.

Strategic planning for research programmes.

Designing in-vivo experiments.

Case studies of animal welfare issues.

Anatomy and physiology of experimental animals.

Experimental design and application of the 3Rs.

Collection and processing of samples for clinical trials.

Student presentations of experimental designs. Credits.

Directive 2010/63/EU on the protection of animals used for scientific purposes, adopted on 22 September 2010.

Guide for the Care and Use of Laboratory Animals, Institute of Laboratory Animal Resources, National Academy Press, Washington DC., 1996

Laboratory Animal Medicine (Second Edition), J.G. Fox, L.C. Anderson, F.M. Loew and F.W. Quimby (Eds.), Elsevier Inc. 2002

Laboratory Animal Management and Welfare, S. Wolfensohn and M. Lloyd, Wiley-Blackwell, Oxford University Press, 2013

Continuous assessment:

Seminar work - experimental design in compliance with EU legislation

Conditions for completion of course:

Block completion of lectures and exercises; Seminar work (experimental design protocol); Exam

Final assessment:

Credit and exam - written test (max. total of 100 points ): A - 100-90 %; B - 89-80 %; C - 79-70 %; D - 69-60 %; E – 59-51 %

The subject is provided for minimum of 5 students.