No

The condition is to pass practical exercises and a written exam.

The maximum number of missed exercises is 3 per semester. One exercise can be recognized without compensation. Substitutions of exercises are usually carried out in the 14th to 15th week of the semester. Lectures are not compulsory. Consultations are possible after agreement with the teacher.

Completion of the course will provide students with the ability to apply the knowledge gained from genetics in the clinical veterinary practice of farm and companion animals. The student will gain an overview of current trends in veterinary genetics and modern animal biotechnology.

Introduction to clinical genetics, Fundamentals of cytogenetics and its importance, overview of hereditary developmental disorders of animals, multifactorial genetic diseases, behavioral genetics, neurogenetics, hereditary fertility disorders, genetics and carcinogenesis, gene therapy, modern directions in biotechnology - animal cloning and transgenesis, genome modification, ethical aspects of clinical genetics and biotechnology.

LECTURES

1.Introduction to clinical genetics.

2.Basic of cytogenetics  chromosomes and karyotypes of domestic animals.

3.Overview of chromosome aberrations and their relationship to animal health

4.Hereditary developmental disorders of livestock. Genes with lethal effect.

5.Genetics of animal coat colour in relation to hereditary diseases.

6.Genetics of fertility disorders.

7.Mutagenesis, teratogenesis and carcinogenesis. Genetics and cancer.

8. Overview of multifactorial diseases.

9. Health heritage control.

10. Gene therapy.

11. Animal genome analysis  GWAS

12. Cloning of animals and preparation of transgenic livestock in relation to their health status.

13. Ethical aspects of clinical genetics and modern biotechnology.

PRACTICALS

1.Genetic counselling  the use of pedigrees in the study of the transmission of hereditary diseases in families.

2.Practical preparation of slides for cytogenetic analysis.

3.Microscopic observation of metaphases of livestock and companion animals. Comparison of the number and morphology of chromosomes.

4.Developmental disorders of companion animals.

5.Genetics of coat color.

6. Sexual development disorders - cases from clinical practice.

7. Mutagenicity tests.

8.Neurogenetics. Behavioral genetics. Genetic and different types of addictions.

9. DNA diagnostics of hereditary diseases.

10.Gene therapy in veterinary practice.

11. Editing the human and animal genomes. Descendants of three parents.

12. Health and ethical aspects of cloning and construction of transgenic animals.

13. Economic and legal issues of modern biotechnology.

Credit test.

RECOMMENDED:

1. Nicholas, F. W.: Introduction to Veterinary Genetics, Blackwell Publishing, 2010

2. Jorde, L. B. et al.: Medical Genetics, Elsevier, 2016.

OPTIONAL

o Strachnan, T.: Genetics and Genomics in Medicine, Garland Science, 2015

o Singh, B.: Advances in Animal Biotechnology, Springer, 2019

Content prerequisite:

N

Continuous assessment:

No

Conditions for completion of course:

The condition is to pass practical exercises and a written exam.

The maximum number of missed exercises is 3 per semester. One exercise can be recognized without compensation. Substitutions of exercises are usually carried out in the 14th to 15th week of the semester. Lectures are not compulsory. Consultations are possible after agreement with the teacher.

Final assessment:

Written exam.