Subject Radiobiology

1.Credit:

- participation on lectures and practicals according to study regulations valid for the given academic year

- preparation and hand-over of seminar works from selected list of topic

- credit test: achieved number of point required or 51% and more success rate

- participation on the all practicals

- reports from selected practicals

2. Exam topics:

- according to the study plan - topics covered by lectures and practical lessons

- written final credit test (51 % and more success rate)

- absence (practical lessons) - will be handled in line with study regulations valid for the given academic year (possible absence for 1 lesson, absence for another 2 lessons must be replaced) - lesson substitution is possible only in the same week (with another study group) - requires approval of the lesson lecturer

Radiobiology (also known as radiation biology) is a branch of biology dealing with the effects of radiation or radioactive materials on biological systems. The aim of the education process is to prepare students for further study at the University of Veterinary Medicine and Pharmacy in Košice. Help them understand the importance of the effects of ionizing radiation on the health of the organism and the use of radiation, especially in medicine and food industry. The students will know the basics and terms of radiobiology after passing the subject. It is important for a veterinary medical student to understand the essential rules, differences, mechanisms of radiation effect at the level of cells and tissues and the organism, radiation protection, clinical manifestations/radiation syndromes of acute and late effects of ionizing radiation due to radiation sickness.

The content focus of the subject is as follows: The students will gain information and knowledge about basic radiobiological concepts, about protection against the effects of ionizing radiation on the body, about the use of diagnostic methods in the overall assessment of health status and/or contamination of various substances. The students will receive basic information and orientation in Radiobiology. It is important for a veterinary medical student to understand the essential rules, differences, mechanisms of radiation effect at the level of cells and tissues and the organism, radiation protection, clinical manifestations/radiation syndromes of acute and late effects of ionizing radiation due to radiation sickness. The system of protection against ionizing radiation as well as the methods of radioactivity control are based on knowledge about the biological effects of radiation and knowledge about the relationship between radiation dose and body health. Tissues of the organism express different sensitivity to radiation represented by particular types of particles emissions according to macroscopical and microscopical changes in organism after radiation exposure.

PRACTICAL LESSONS:

1. Introduction. Protection against external and internal radiation. Workplaces with radioactive substances Assigments of topics of seminar works.

2. Methods of radioactivity control.

3. Methods of detection of radiation effect on the embryonic development.

4. Changes in carbohydrate metabolism after radiation.

5. Genetic consequences of radiation – Mutations.

6. Changes in enzymes after radiation.

7. Radiation effects on cellular level.

8. Heritable genetics effect of radiation.

9. Changes in lipid metabolism after radiation.

10. Late effects of IR: radiation carcinogenesis.

11. Credit test.

12. Macroscopic changes and post-radiation changes in peripheral blood.

13. Handover of seminar works.

LECTURES:

1.Introduction: Radiation and life. Short history of radiation biology.

2. Basic physics of ionozing radiation. Kinds of ionizing radiation. Units of radioactivity and ionizing radiation.

3. Effect of radiation on the embryonic development.

4. Effects of IR on nuclear acids and proteins.

5. Genetic consequences of radiation – Mutations.

6. Mechanism of the action of IR on living systems. Direct and indirect effect of IR. Dose distribution in living organism.

7. Radiation effects cellular level.

8. Heritable genetics effect of radiation.

9. Pathophysiology of ionizing radiation. Radiation syndromes.

10. Late effects of IR: radiation carcinogenesis.

11. Health effects of the most important radionuclides. Ways of input of radionuclides into human body and their fate in the body. Mechanism of the excretion of radionuclides.

12. Radiation and immunity.

13. Radiation and nuclear science.

Lecture and practice presentations in Moodle system.

Szabóová, Renáta - Beňová, Katarína - Galdíková, Martina - Herich, Robert - Holečková, Beáta - Schwarzbacherová, Viera. Essentials of Radiobiology. University of Veterinary Medicine and Pharmacy in Košice, 2022. Under revision.

Beňová, Katarína - Šmajda, Beňadik - Mičková, Helena - Čipáková, A.: Radiobiology. 1 elektronický optický disk (CD-ROM) - Košice : University of Veterinary Medicine, 2007. - ISBN 978-80-8077-053-2

Content prerequisite:

Subject Biology

Continuous assessment:

- evaluation of the participation on all practical lessons

- handover of seminar work on a selected topic

- credit test with 20 questions with yes/no answers and with one correct answer out of three options in one question is at least 51 % and more (up to 100 %) correct answers

Conditions for completion of course:

Subject Radiobiology

1.Credit:

- participation on lectures and practicals according to study regulations valid for the given academic year

- preparation and hand-over of seminar works from selected list of topic

- credit test: achieved number of point required or 51% and more success rate

- participation on the all practicals

- reports from selected practicals

2. Exam topics:

- according to the study plan - topics covered by lectures and practical lessons

- written final credit test (51 % and more success rate)

- absence (practical lessons) - will be handled in line with study regulations valid for the given academic year (possible absence for 1 lesson, absence for another 2 lessons must be replaced) - lesson substitution is possible only in the same week (with another study group) - requires approval of the lesson lecturer

Final assessment:

Final evaluation – credit ecquirement incudes: 100 % participation in practical lessons (possible absence for 1 lesson, absence for another 2 lessons must be replaced), successful completion of credit test and working-out of seminar work on a selected topic – weight 100 %. Final written test at the end of semester - weight 100 %, 20 questions in credit test and 30 questions in final test with yes/no answers and achieving the required number of correct answers is at least 51 % and more (up to 100 %) correct answers (a point scale is part of each test). Test evaluation is as follows: in the interval A - E, Fx - failed.

Name of the course: Radiobiology, 2GVM, Form: full-time, daily form, winter semester (lecture/practical lessons: 1/2e), Number of credits: 3, Head of the study subject: Renáta Szabóová, DVM, PhD.