Block completion of lectures and exercises;

Student presentation - credit;

Exam test

Training in animal welfare, diseases of laboratory animals, husbandry management in laboratory facilities.

Lectures:

Lecture: 1. Laboratory animals in biomedical research - legislation basics and requirements, 3Rs.

Lecture: 2. Basics of animal physiology, species peculiarities used in research.

Lecture: 3. Fixation and handling of laboratory animals.

Lecture: 4. Diseases of laboratory animals

Lecture: 5. Anesthesia and analgesia principles of clinical experiments in animals.

Lecture: 6. Sampling during clinical trials. Case studies and class discussions to provide materials and ideas for school presentations.

Practicals:

Anatomy and physiology of experimental animals.

Husbandry in experimental animal stable.

Evidence and marking of experimental animals.

Clinical examination of animals in experimental facilities.

3Rs in animal experimentations and facilities.

Husbandry in practice.

Prevention and health monitoring of laboratory animals.

Anatomy, physiological peculiarities and use of small mammals (mouse, rat, rabbit, guinea pig) in clinical trials.

Anatomy, physiological peculiarities and use of poultry in clinical trials.

Application of drugs and anesthesia during collection of clinical specimens.

Euthanasia and disposal of biological material.

Student presentations in application of the 3Rs. Credits.

Directive 2010/63/EU on the protection of animals used for scientific purposes, adopted on 22 September 2010.

Guide for the Care and Use of Laboratory Animals, Institute of Laboratory Animal Resources, National Academy Press, Washington DC., 1996.

Laboratory Animal Medicine (Second Edition), J.G. Fox, L.C. Anderson, F.M. Loew and F.W. Quimby (Eds.), Elsevier Inc. 2002.

Laboratory Animal Management and Welfare, S. Wolfensohn and M. Lloyd, Wiley-Blackwell, Oxford University Press, 2013.

Continuous assessment:

student presentation - credit

Conditions for completion of course:

Block completion of lectures and exercises;

Student presentation - credit;

Exam test

Final assessment:

Credit and exam - written test (max . total of 100 points ): A - 100-90 %; B - 89-80 %; C - 79-70 %; D - 69-60 %; E – 59-51 %

The subject is provided for minimum of 5 students.