Form of teaching: Lecture / Exercise Recommended scope of teaching (in hours): weekly: 1 hour lecture / 4 hours exercise - of which 80% self-study. Total student load: 130 hours of which: lectures: 26 hours, practical exercises 104 hours, of which - study of scientific and professional literature on the assigned topic, study of methods of laboratory analysis, carrying out experimental laboratory activities, evaluation of experimental results, writing a seminar paper: preparation for the presentation of the seminar paper, presentation of the seminar paper and examination. Method of study: presentation method

The learning outcomes are verified by the preparation of a seminar thesis, its defence and a final examination

The aim of food toxicology is to give graduates an informed knowledge of the course of poisoning, biotransformation and distribution of toxic substances, including pharmaceuticals, in the animal body. Emphasis will be placed mainly on chronic, clinically unmanifest poisonings, which may be caused by prolonged intake of xenobiotics from food or feed in humans and animals. The course will mainly focus on: characterization of poisonous substances, (LD50 and LC50, accumulation and persistence, calculation of LD50 values), definition of acute and chronic toxicity, description of hidden - non-manifest effects of poisons (carcinogenicity, teratogenicity, embryotoxicity, allergies and immunopathological changes), description of endogenous and exogenous factors influencing toxicity of poisons, elucidation of methods for estimating the risks of chemicals to humans, animals and the environment, characterization of residues of pharmaceutical and non-medicinal chemicals and naturally occurring food poisons, and description of their toxicological effects on humans and animals. It will also include an introduction to national and European legislation in toxicology

1. Gupta R.C. a Aggarwal M. 2012. Veterinary toxicology, Basic and clinical principles, (ed Gupta et al.), pp. 1438, ISBN: 978-0-12-385926-6 2. Legáth a kol.: Špeciálna toxikológia, 1. vyd. Košice : UVLF v Košiciach, 2019. 377 s. ISBN 978-80-8077-656-5. 3. Legáth, J: Úvod do všeobecnej toxikológie. Študijné materiály, UVL, 2003 3. Legáth, J. a kol.: Odhad miery rizika chemických látok pre domáce, hospodárske a voľne žijúce zvieratá, včely a vodné živočíchy. DATAHELP, Košice 1997, 102 s., ISBN 80-88867-10-X 5. Piskáč, Kačmár: Veterinárna toxikológia, 1985 6. Bugarský, A. a kol.: Súdne veterinárske lekárstvo – základy. ISBN 80-88985-97-8, 288 s. 7. other available literature, with emphasis on articles published in reputable toxicology journals

Content prerequisite:

Knowledge of biology, biochemistry, pathological physiology is essential

Conditions for completion of course:

Form of teaching: Lecture / Exercise Recommended scope of teaching (in hours): weekly: 1 hour lecture / 4 hours exercise - of which 80% self-study. Total student load: 130 hours of which: lectures: 26 hours, practical exercises 104 hours, of which - study of scientific and professional literature on the assigned topic, study of methods of laboratory analysis, carrying out experimental laboratory activities, evaluation of experimental results, writing a seminar paper: preparation for the presentation of the seminar paper, presentation of the seminar paper and examination. Method of study: presentation method

Final assessment:

Course grades A (91-100%) B (81-90%) C (71-80%) D(61-70%) E (51-60%) FX (50% or less)