No.

Students are obliged

to absolve majority of lectures (70%) and practical lessons; to compensate missed practicals (according to rules of the Study Guide) providing knowledge of practiced topics; to pass the1st written test (51% of correct answers) and a final test (51% of correct answers); to be successfull in a final written exam (min. 51%).

All information in MOODLE.

The subject focuses on the study of essential genetic principles in the field of general genetics (Mendelian genetics, immunogenetics, population genetics) and molecular genetics. It is an introduction to veterinary genetics and focuses on necessary knowledge about animal genetic diseases. Students will be able to analyse genetic problems, to formulate principles/conclusions as well as to determine the type of disease inheritance and to evaluate the genetic risk for progeny/population. Students will also be familiar with the application of molecular biology in veterinary medicine.

Subject consists of the following parts: Mendel´s laws and their application. Punnet square. Calculation of genotype and phenotype cleavage ratios. Gene interactions (pleiotrophy, recessive epistasis). Complete and incomplete gene linkage. Calculation of gene linkage power and application in veterinary medicine. Genetics of sex. Sex chromosome characteristics. sex linked traits, anomalies in sexual determination Immunogenetics. Blood groups and animal blood typing in veterinary medicine Population genetics of qualitative and quantitative traits. Calculation of genetic risk for population and individuum. Epigenetic mechanisms in relation to changes in gene expression. Recombinant DNA technologies. Perspectives and application of molecular genetics in veterinary medicine. Review of the most important anmial genetic diseases. The course contents 26 hrs of lectures and 26 hrs of practicals.

LECTURES 1 Introduction to Genetics. Molecular basis of inheritance. 2. Genetic terminology. Mendel´s laws. Mendel´s principle of independent assortment of genes. 3. Chromosomal theory of inheritance. Gene linkage: complete and incomplete. Application in veterinary medicine. 4. Genetics of sex. Sex-linked traits. Anomalies in the sexual determination. 5. Immunogenetics. Inheritance of blood groups and animal paternity testing in veterinary medicine. 6. Types of single-gene coded inheritance (Mendelian). Examples of single-coded diseases. 7. Pedigree tree analysis in genetic prognosis – apriori and aposteriori genetic risk. 8. Population genetics of qualitative traits: Hardy-Weinberg law Application in veterinary medicine. 9. Population genetics of quantitative traits. Inbreeding and heterosis. 10. Developmental genetics. Overview of multifactorial diseases. 11. Introduction to epigenetics. 12. Molecular genetics – essential laboratory methods. 13. Molecular genetics in veterinary practice. PRACTICALS 1. Mitosis and meiosis. Detection of cell cycle stage in onion cells and mouse testicular tissue. 2. Mendelian laws, phenotype and genotype cleavage ratio. Application in veterinary medicine. 3. Independent assortment of alleles. Intergenic relations (epistasis, pleiotrophy). 4. Complete and incomplete gene linkage. 5. Gene mapping – three point test. 6. Sex-linked inheritance. 7. Blood groups of animals. Blood tests in the paternity detection. 1st WRITTEN TEST. 8. Pedigree-tree analysis. Determination of apriori risk for offspring using pedigree-tree. 9. Aposteriori genetic risk. 10. Population genetics of qualitative traits. Hardy-Weinberg law in genetic prognosis: application in veterinary medicine. 11. Population genetics of quantitative traits. Heritability coefficient h2 and its relation to diseases. 12. Inbreeding. Calculation of the inbreeding coefficient (Fx): application in veterinary medicine. 13. Application of DNA analysis in veterinary medicine. FINAL TEST.

LIST OF COMPULSORY TITLES 1. Šiviková, K., Dianovský, J., Holečková, B: Introduction to Veterinary Genetics. UVMP Košice, 2017. 2. Holečková, B., Galdíková, M., Schwarzbacherová, V., Koleničová, S.: Lessons in Genetics: A Practical Approach I. (for study programme GVM), UVMP Košice, 2022.3. Nicholas, F. W.: Introduction to Veterinary Genetics. Wiley-Blackwell, 2010. LIST OF PROPOSED TITLES Luptáková, L., Tomko, M., Valenčáková, A., Špalková, M.: Biology for Veterinary Medicine, 2018 Jorde, L. B., Carey, J. C., Bamshad, B. J.: Medical Genetics. 5th Ed., Elsevier, 2016 Nicholas, F. W.: Veterinary Genetics, Oxford, 1987

Content prerequisite:

No

Continuous assessment:

the 1.st written test (51% of correct answers) and a final written test (51% of correct answers);

Conditions for completion of course:

Students are obliged

to absolve majority of lectures (70%) and practical lessons; to compensate missed practicals (according to rules of the Study Guide) providing knowledge of practiced topics; to pass the1st written test (51% of correct answers) and a final test (51% of correct answers); to be successfull in a final written exam (min. 51%).

All information in MOODLE.

Final assessment:

The 1.st written test (51% of correct answers) Final written test (51% of correct answers) Final written exam (min. 51%) The final mark: 20% for credit plus 80% for exam